Analogs of JHU75528, a PET ligand for imaging of cerebral cannabinoid receptors (CB1): development of ligands with optimized lipophilicity and binding affinity

Cyano analogs of Rimonabant with high binding affinity for the cerebral cannabinoid receptor (CB1) and with optimized lipophilicity have been synthesized as potential positron emission tomography (PET) ligands. The best ligands of the series are optimal targets for the future radiolabeling with PET...

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Hlavní autoři: Fan, Hong, Kotsikorou, Evangelia, Hoffman, Alexander F., Ravert, Hayden T., Holt, Daniel, Hurst, Dow P., Lupica, Carl R., Reggio, Patricia H., Dannals, Robert F., Horti, Andrew G.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2728551/
https://ncbi.nlm.nih.gov/pubmed/18511157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2008.03.040
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