Synthesis and Pharmacology of 1-Methoxy Analogs of CP-47,497

Three 1-methoxy analogs of CP-47,497 (7, 8 and 19) have been synthesized and their affinities for the cannabinoid CB(1) and CB(2) receptors have been determined. Although these compounds exhibit selectivity for the CB(2) receptor none have significant affinity for either receptor. Modeling and recep...

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Main Authors: Huffman, John W., Hepburn, Seon A., Reggio, Patricia H., Hurst, Dow P., Wiley, Jenny L., Martin, Billy R.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2920039/
https://ncbi.nlm.nih.gov/pubmed/20621488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2010.06.054
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