Chromatin stability as a target for cancer treatment

por Gurova, Katerina V
Publicado en Bioessays (2019)

Inflammation and p53: A Tale of Two Stresses

por Gudkov, Andrei V., Gurova, Katerina V., Komarova, Elena A.
Publicado 2011

Inhibition of the FACT Complex Reduces Transcription from the Human Cytomegalovirus Major Immediate Early Promoter in Models of Lytic and Latent Replication

por O'Connor, Christine M., Nukui, Masatoshi, Gurova, Katerina V., Murphy, Eain A.
Publicado en J Virol (2016)

Uncovering the fine print of the CreER(T2)-LoxP system while generating a conditional knockout mouse model of Ssrp1 gene

por Sandlesh, Poorva, Juang, Thierry, Safina, Alfiya, Higgins, Michael J., Gurova, Katerina V.
Publicado en PLoS One (2018)

Prostate Cancer Cells Tolerate a Narrow Range of Androgen Receptor Expression and Activity

por Tararova, Natalia D., Narizhneva, Natalya, Krivokrisenko, Vadim, Gudkov, Andrei V., Gurova, Katerina V.
Publicado 2007

Complex mutual regulation of facilitates chromatin transcription (FACT) subunits on both mRNA and protein levels in human cells

por Safina, Alfiya, Garcia, Henry, Commane, Mairead, Guryanova, Olga, Degan, Seamus, Kolesnikova, Kateryna, Gurova, Katerina V
Publicado 2013

Role of chromatin damage and chromatin trapping of FACT in mediating the anticancer cytotoxicity of DNA-binding small molecule drugs

por Nesher, Elimelech, Safina, Alfiya, Aljahdali, Ieman, Portwood, Scott, Wang, Eunice S, Koman, Igor, Wang, Jianmin, Gurova, Katerina V.
Publicado en Cancer Res (2018)

Histone Chaperone FACT and Curaxins: Effects on Genome Structure and Function

por Chang, Han-Wen, Nizovtseva, Ekaterina V., Razin, Sergey V., Formosa, Tim, Gurova, Katerina V., Studitsky, Vasily M.
Publicado en J Cancer Metastasis Treat (2019)

Prevention of Chromatin Destabilization by FACT Is Crucial for Malignant Transformation

por Sandlesh, Poorva, Safina, Alfiya, Goswami, Imon, Prendergust, Laura, Rosario, Spenser, Gomez, Eduardo C., Wang, Jianmin, Gurova, Katerina V.
Publicado en iScience (2020)

Small-Molecule Inhibitor Which Reactivates p53 in Human T-Cell Leukemia Virus Type 1-Transformed Cells

por Jung, Kyung-Jin, Dasgupta, Arindam, Huang, Keven, Jeong, Soo-Jin, Pise-Masison, Cynthia, Gurova, Katerina V., Brady, John N.
Publicado 2008

Inhibition of Encephalomyocarditis Virus and Poliovirus Replication by Quinacrine: Implications for the Design and Discovery of Novel Antiviral Drugs

por Gasparian, Alexander V., Neznanov, Nickolay, Jha, Sujata, Galkin, Oleksandr, Moran, John J., Gudkov, Andrei V., Gurova, Katerina V., Komar, Anton A.
Publicado 2010

Curaxin CBL0137 eradicates drug resistant cancer stem cells and potentiates efficacy of gemcitabine in preclinical models of pancreatic cancer

por Burkhart, Catherine, Fleyshman, Daria, Kohrn, Rachael, Commane, Mairead, Garrigan, Jennifer, Kurbatov, Vadim, Toshkov, Ilya, Ramachandran, Rajesh, Martello, Laura, Gurova, Katerina V.
Publicado en Oncotarget (2014)

A translational hepatic artery infusion (HAI) model for hepatocellular carcinoma in woodchucks

por Kim, Minhyung, Powers, Colin A., Curtin, Leslie I., Fisher, Daniel T., Sexton, Sandra, Gurova, Katerina V., Skitzki, Joseph J., Iyer, Renuka V.
Publicado en J Surg Res (2020)

Small-Molecule Xenomycins Inhibit All Stages of the Plasmodium Life Cycle

por Erath, Jessey, Gallego-Delgado, Julio, Xu, Wenyue, Andriani, Grasiella, Tanghe, Scott, Gurova, Katerina V., Gudkov, Andrei, Purmal, Andrei, Rydkina, Elena, Rodriguez, Ana
Publicado en Antimicrob Agents Chemother (2015)

Anticancer drug candidate CBL0137, which inhibits histone chaperone FACT, is efficacious in preclinical orthotopic models of temozolomide-responsive and -resistant glioblastoma

por Barone, Tara A, Burkhart, Catherine A, Safina, Alfiya, Haderski, Gary, Gurova, Katerina V, Purmal, Andrei A, Gudkov, Andrei V, Plunkett, Robert J
Publicado en Neuro Oncol (2017)

Small molecule screening reveals a transcription-independent pro-survival function of androgen receptor in castration-resistant prostate cancer

por Narizhneva, Natalia V., Tararova, Natalia D., Ryabokon, Petro, Shyshynova, Inna, Prokvolit, Anatoly, Komarov, Pavel G., Purmal, Andrei A., Gudkov, Andrei V., Gurova, Katerina V.
Publicado 2009

Anti-malaria drug blocks proteotoxic stress response: Anti-cancer implications

por Neznanov, Nickolay, Gorbachev, Anton V., Neznanova, Lubov, Komarov, Andrei P., Gurova, Katerina V., Gasparian, Alexander V., Banerjee, Amiya K., Almasan, Alexandru, Fairchild, Robert L., Gudkov, Andrei V.
Publicado 2009

Preclinical validation of a single-treatment infusion modality that can eradicate extremity melanomas

por Kim, Minhyung, Neznanov, Nickolay, Wilfong, Chandler D., Fleyshman, Daria I., Purmal, Andrei, Haderski, Gary, Stanhope-Baker, Patricia, Burkhart, Catherine A., Gurova, Katerina V., Gudkov, Andrei V., Skitzki, Joseph J.
Publicado en Cancer Res (2016)

Mechanism of FACT removal from transcribed genes by anticancer drugs curaxins

por Chang, Han-Wen, Valieva, Maria E., Safina, Alfiya, Chereji, Răzvan V., Wang, Jianmin, Kulaeva, Olga I., Morozov, Alexandre V., Kirpichnikov, Mikhail P., Feofanov, Alexey V., Gurova, Katerina V., Studitsky, Vasily M.
Publicado en Sci Adv (2018)

Pharmacological targeting of the histone chaperone complex FACT preferentially eliminates glioblastoma stem cells and prolongs survival in preclinical models

por Dermawan, Josephine Kam Tai, Hitomi, Masahiro, Silver, Daniel J., Wu, Qiulian, Sandlesh, Poorva, Sloan, Andrew E., Purmal, Andrei A., Gurova, Katerina V., Rich, Jeremy N., Lathia, Justin D., Stark, George R., Venere, Monica
Publicado en Cancer Res (2016)