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Histone Chaperone FACT and Curaxins: Effects on Genome Structure and Function

The histone chaperone FACT plays important roles in essentially every chromatin-associated process and is an important indirect target of the curaxin class of anti-cancer drugs. Curaxins are aromatiс compounds that intercalate into DNA and can trap FACT in bulk chromatin, thus interfering with its d...

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Bibliographische Detailangaben
Veröffentlicht in:J Cancer Metastasis Treat
Hauptverfasser: Chang, Han-Wen, Nizovtseva, Ekaterina V., Razin, Sergey V., Formosa, Tim, Gurova, Katerina V., Studitsky, Vasily M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6919649/
https://ncbi.nlm.nih.gov/pubmed/31853507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.20517/2394-4722.2019.31
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