Mechanism of FACT removal from transcribed genes by anticancer drugs curaxins

Human FACT (facilitates chromatin transcription) is a multifunctional protein complex that has histone chaperone activity and facilitates nucleosome survival and transcription through chromatin. Anticancer drugs curaxins induce FACT trapping on chromatin of cancer cells (c-trapping), but the mechani...

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Bibliografski detalji
Izdano u:Sci Adv
Glavni autori: Chang, Han-Wen, Valieva, Maria E., Safina, Alfiya, Chereji, Răzvan V., Wang, Jianmin, Kulaeva, Olga I., Morozov, Alexandre V., Kirpichnikov, Mikhail P., Feofanov, Alexey V., Gurova, Katerina V., Studitsky, Vasily M.
Format: Artigo
Jezik:Inglês
Izdano: American Association for the Advancement of Science 2018
Teme:
Research Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6221510/
https://ncbi.nlm.nih.gov/pubmed/30417101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aav2131
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