Curaxins: Anticancer Compounds that Simultaneously Suppress NF-κB and Activate p53 by Targeting FACT

Effective eradication of cancer requires treatment directed against multiple targets. The p53 and nuclear factor κB (NF-κB) pathways are dysregulated in nearly all tumors, making them attractive targets for therapeutic activation and inhibition, respectively. We have isolated and structurally optimi...

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Publicat a:Sci Transl Med
Autors principals: Gasparian, Alexander V., Burkhart, Catherine A., Purmal, Andrei A., Brodsky, Leonid, Pal, Mahadeb, Saranadasa, Madhi, Bosykh, Dmitry A., Commane, Mairead, Guryanova, Olga A., Pal, Srabani, Safina, Alfiya, Sviridov, Sergey, Koman, Igor E., Veith, Jean, Komar, Anton A., Gudkov, Andrei V., Gurova, Katerina V.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6281439/
https://ncbi.nlm.nih.gov/pubmed/21832239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3002530
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