Curaxins: Anticancer Compounds that Simultaneously Suppress NF-κB and Activate p53 by Targeting FACT

Effective eradication of cancer requires treatment directed against multiple targets. The p53 and nuclear factor κB (NF-κB) pathways are dysregulated in nearly all tumors, making them attractive targets for therapeutic activation and inhibition, respectively. We have isolated and structurally optimi...

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Detalhes bibliográficos
Publicado no:Sci Transl Med
Main Authors: Gasparian, Alexander V., Burkhart, Catherine A., Purmal, Andrei A., Brodsky, Leonid, Pal, Mahadeb, Saranadasa, Madhi, Bosykh, Dmitry A., Commane, Mairead, Guryanova, Olga A., Pal, Srabani, Safina, Alfiya, Sviridov, Sergey, Koman, Igor E., Veith, Jean, Komar, Anton A., Gudkov, Andrei V., Gurova, Katerina V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6281439/
https://ncbi.nlm.nih.gov/pubmed/21832239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3002530
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