Curaxins: Anticancer Compounds that Simultaneously Suppress NF-κB and Activate p53 by Targeting FACT

Effective eradication of cancer requires treatment directed against multiple targets. The p53 and nuclear factor κB (NF-κB) pathways are dysregulated in nearly all tumors, making them attractive targets for therapeutic activation and inhibition, respectively. We have isolated and structurally optimi...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Sci Transl Med
Main Authors: Gasparian, Alexander V., Burkhart, Catherine A., Purmal, Andrei A., Brodsky, Leonid, Pal, Mahadeb, Saranadasa, Madhi, Bosykh, Dmitry A., Commane, Mairead, Guryanova, Olga A., Pal, Srabani, Safina, Alfiya, Sviridov, Sergey, Koman, Igor E., Veith, Jean, Komar, Anton A., Gudkov, Andrei V., Gurova, Katerina V.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6281439/
https://ncbi.nlm.nih.gov/pubmed/21832239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3002530
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares