Curaxin CBL0137 eradicates drug resistant cancer stem cells and potentiates efficacy of gemcitabine in preclinical models of pancreatic cancer

Pancreatic ductal adenocarcinoma (PDA) continues to be one of the deadliest cancers due to the absence of effective treatment. Curaxins are a class of small molecules with anti-cancer activity demonstrated in different models of cancer in mice. The lead curaxin compound, CBL0137, recently entered Ph...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Burkhart, Catherine, Fleyshman, Daria, Kohrn, Rachael, Commane, Mairead, Garrigan, Jennifer, Kurbatov, Vadim, Toshkov, Ilya, Ramachandran, Rajesh, Martello, Laura, Gurova, Katerina V.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2014
Assuntos:
Priority Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294371/
https://ncbi.nlm.nih.gov/pubmed/25402820
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