Functional roles of the DNA-binding HMGB domain in the histone chaperone FACT in nucleosome reorganization

The essential histone chaperone FACT (facilitates chromatin transcription) promotes both nucleosome assembly and disassembly. FACT is a heterodimer of Spt16 with either SSRP1 or Pob3, differing primarily by the presence of a high-mobility group B (HMGB) DNA-binding domain furnished only by SSRP1. Ye...

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Vydáno v:J Biol Chem
Hlavní autoři: McCullough, Laura L., Connell, Zaily, Xin, Hua, Studitsky, Vasily M., Feofanov, Alexey V., Valieva, Maria E., Formosa, Tim
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2018
Témata:
DNA and Chromosomes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5912460/
https://ncbi.nlm.nih.gov/pubmed/29514976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000199
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