Prevention of Chromatin Destabilization by FACT Is Crucial for Malignant Transformation

Histone chaperone FACT is commonly expressed and essential for the viability of transformed but not normal cells, and its expression levels correlate with poor prognosis in patients with cancer. FACT binds several components of nucleosomes and has been viewed as a factor destabilizing nucleosomes to...

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Publicado no:iScience
Main Authors: Sandlesh, Poorva, Safina, Alfiya, Goswami, Imon, Prendergust, Laura, Rosario, Spenser, Gomez, Eduardo C., Wang, Jianmin, Gurova, Katerina V.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7267732/
https://ncbi.nlm.nih.gov/pubmed/32498018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101177
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