Anti-malaria drug blocks proteotoxic stress response: Anti-cancer implications

The number of physical conditions and chemical agents induce accumulation of misfolded proteins creating proteotoxic stress. This leads to activation of adaptive pro-survival pathway, known as heat shock response (HSR), resulting in expression of additional chaperones. Several cancer treatment appro...

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Hlavní autoři: Neznanov, Nickolay, Gorbachev, Anton V., Neznanova, Lubov, Komarov, Andrei P., Gurova, Katerina V., Gasparian, Alexander V., Banerjee, Amiya K., Almasan, Alexandru, Fairchild, Robert L., Gudkov, Andrei V.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2923591/
https://ncbi.nlm.nih.gov/pubmed/19901558
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