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Proteotoxic stress targeted therapy (PSTT): induction of protein misfolding enhances the antitumor effect of the proteasome inhibitor bortezomib

Proteotoxic stress (PS) is generated in cells under a variety of conditions involving accumulation of misfolded proteins. To avoid the toxicity of unmitigated PS, cells activate the heat shock response (HSR). HSR involves upregulation of factors such as ubiquitin and the non-housekeeping chaperone H...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Neznanov, Nickolay, Komarov, Andrei P., Neznanova, Lubov, Stanhope-Baker, Patricia, Gudkov, Andrei V.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Impact Journals LLC 2011
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3260823/
https://ncbi.nlm.nih.gov/pubmed/21444945
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