Anticancer drug candidate CBL0137, which inhibits histone chaperone FACT, is efficacious in preclinical orthotopic models of temozolomide-responsive and -resistant glioblastoma

Por Barone, Tara A, Burkhart, Catherine A, Safina, Alfiya, Haderski, Gary, Gurova, Katerina V, Purmal, Andrei A, Gudkov, Andrei V, Plunkett, Robert J
Publicado no Neuro Oncol (2017)

Small molecule screening reveals a transcription-independent pro-survival function of androgen receptor in castration-resistant prostate cancer

Por Narizhneva, Natalia V., Tararova, Natalia D., Ryabokon, Petro, Shyshynova, Inna, Prokvolit, Anatoly, Komarov, Pavel G., Purmal, Andrei A., Gudkov, Andrei V., Gurova, Katerina V.
Publicado em 2009

Pharmacological targeting of the histone chaperone complex FACT preferentially eliminates glioblastoma stem cells and prolongs survival in preclinical models

Por Dermawan, Josephine Kam Tai, Hitomi, Masahiro, Silver, Daniel J., Wu, Qiulian, Sandlesh, Poorva, Sloan, Andrew E., Purmal, Andrei A., Gurova, Katerina V., Rich, Jeremy N., Lathia, Justin D., Stark, George R., Venere, Monica
Publicado no Cancer Res (2016)

The Toll-Like Receptor 5 Agonist Entolimod Mitigates Lethal Acute Radiation Syndrome in Non-Human Primates

Por Krivokrysenko, Vadim I., Toshkov, Ilia A., Gleiberman, Anatoli S., Krasnov, Peter, Shyshynova, Inna, Bespalov, Ivan, Maitra, Ratan K., Narizhneva, Natalya V., Singh, Vijay K., Whitnall, Mark H., Purmal, Andrei A., Shakhov, Alexander N., Gudkov, Andrei V., Feinstein, Elena
Publicado no PLoS One (2015)

Curaxins: Anticancer Compounds that Simultaneously Suppress NF-κB and Activate p53 by Targeting FACT

Por Gasparian, Alexander V., Burkhart, Catherine A., Purmal, Andrei A., Brodsky, Leonid, Pal, Mahadeb, Saranadasa, Madhi, Bosykh, Dmitry A., Commane, Mairead, Guryanova, Olga A., Pal, Srabani, Safina, Alfiya, Sviridov, Sergey, Koman, Igor E., Veith, Jean, Komar, Anton A., Gudkov, Andrei V., Gurova, Katerina V.
Publicado no Sci Transl Med (2011)