Pharmacological targeting of the histone chaperone complex FACT preferentially eliminates glioblastoma stem cells and prolongs survival in preclinical models

The nearly universal recurrence of glioblastoma (GBM) is driven in part by a treatment-resistant subpopulation of GBM stem cells (GSCs). To identify improved therapeutic possibilities, we combined the EGFR/HER2 inhibitor lapatinib with a novel small molecule, CBL0137, which inhibits FACT (Facilitate...

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Publicado no:Cancer Res
Main Authors: Dermawan, Josephine Kam Tai, Hitomi, Masahiro, Silver, Daniel J., Wu, Qiulian, Sandlesh, Poorva, Sloan, Andrew E., Purmal, Andrei A., Gurova, Katerina V., Rich, Jeremy N., Lathia, Justin D., Stark, George R., Venere, Monica
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4873320/
https://ncbi.nlm.nih.gov/pubmed/26921329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-2162
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