Tuning up the right signal: chemical and genetic approaches to study GPCR functions

Por Giguere, Patrick M., Kroeze, Wesley K., Roth, Bryan L.
Publicado em 2013

DREADDs: novel tools for drug discovery and development

Por Lee, Hyeong-Min, Giguere, Patrick M., Roth, Bryan L.
Publicado em 2013

G-protein Signaling Modulator-3 Regulates Heterotrimeric G-protein Dynamics through Dual Association with Gβ and Gα(i) Protein Subunits

Por Giguère, Patrick M., Laroche, Geneviève, Oestreich, Emily A., Siderovski, David P.
Publicado em 2012

Structure of the parathyroid hormone receptor C-terminus bound to the G-protein dimer Gβ(1)γ(2)

Por Johnston, Christopher A., Kimple, Adam J., Giguère, Patrick M., Siderovski, David P.
Publicado em 2008

Regulators of G-Protein Signaling and Their Gα Substrates: Promises and Challenges in Their Use as Drug Discovery Targets

Por Kimple, Adam J., Bosch, Dustin E., Giguère, Patrick M., Siderovski, David P.
Publicado em 2011

Design and Synthesis of (2-(5-Chloro-2,2-dimethyl-2,3-dihydrobenzofuran-7-yl)cyclopropyl)methanamine as a Selective Serotonin 2C Agonist

Por Cheng, Jianjun, Giguere, Patrick M., Lv, Wei, Roth, Bryan L., Kozikowski, Alan P.
Publicado no Tetrahedron Lett (2015)

RNA interference screen for RGS protein specificity at muscarinic and protease-activated receptors reveals bidirectional modulation of signaling

Por Laroche, Geneviève, Giguère, Patrick M., Roth, Bryan L., Trejo, JoAnn, Siderovski, David P.
Publicado em 2010

Regulation of the Subcellular Localization of the G-protein Subunit Regulator GPSM3 through Direct Association with 14-3-3 Protein

Por Giguère, Patrick M., Laroche, Geneviève, Oestreich, Emily A., Duncan, Joseph A., Siderovski, David P.
Publicado em 2012

The RGS protein inhibitor CCG-4986 is a covalent modifier of the RGS4 Gα-interaction face

Por Kimple, Adam J., Willard, Francis S., Giguère, Patrick M., Johnston, Christopher A., Mocanu, Viorel, Siderovski, David P.
Publicado em 2007

Addition of 25-hydroxyvitamin D levels to the Deyo-Charlson Comorbidity Index improves 90-day mortality prediction in critically ill patients

Por Mahato, Bisundev, Otero, Tiffany M. N., Holland, Carrie A., Giguere, Patrick T., Bajwa, Ednan K., Camargo, Carlos A., Quraishi, Sadeq A.
Publicado no J Intensive Care (2016)

Molecular Control of δ-Opioid Receptor Signaling

Por Fenalti, Gustavo, Giguere, Patrick M., Katritch, Vsevolod, Huang, Xi-Ping, Thompson, Aaron A., Cherezov, Vadim, Roth, Bryan L., Stevens, Raymond C.
Publicado em 2014

Heterotrimeric G-protein Signaling Is Critical to Pathogenic Processes in Entamoeba histolytica

Por Bosch, Dustin E., Kimple, Adam J., Muller, Robin E., Giguère, Patrick M., Machius, Mischa, Willard, Francis S., Temple, Brenda R. S., Siderovski, David P.
Publicado em 2012

A non-canonical function of Gβ as a subunit of E3 ligase in targeting GRK2 ubiquitylation

Por Zha, Zhengyu, Han, Xiaoran, Smith, Matthew D., Liu, Yang, Giguère, Patrick M., Kopanja, Dragana, Raychaudhuri, Pradip, Siderovski, David P., Guan, Kun-Liang, Lei, Qun-Ying, Xiong, Yue
Publicado no Mol Cell (2015)

G Protein Signaling Modulator-3 Inhibits the Inflammasome Activity of NLRP3

Por Giguère, Patrick M., Gall, Bryan J., Ezekwe, Ejiofor A. D., Laroche, Geneviève, Buckley, Brian K., Kebaier, Chahnaz, Wilson, Justin E., Ting, Jenny P., Siderovski, David P., Duncan, Joseph A.
Publicado no J Biol Chem (2014)

G-protein signaling modulator-3, a gene linked to autoimmune diseases, regulates monocyte function and its deficiency protects from inflammatory arthritis

Por Giguère, Patrick M., Billard, Matthew J., Laroche, Geneviève, Buckley, Brian K., Timoshchenko, Roman G., McGinnis, Marcus W., Esserman, Denise, Foreman, Oded, Liu, Peng, Siderovski, David P., Tarrant, Teresa K.
Publicado em 2012

Optimization of 2-Phenylcyclopropylmethylamines as Selective Serotonin 2C Receptor Agonists and Their Evaluation as Potential Antipsychotic Agents

Por Cheng, Jianjun, Giguère, Patrick M., Onajole, Oluseye K., Lv, Wei, Gaisin, Arsen, Gunosewoyo, Hendra, Schmerberg, Claire M., Pogorelov, Vladimir M., Rodriguiz, Ramona M., Vistoli, Giulio, Wetsel, William C., Roth, Bryan L., Kozikowski, Alan P.
Publicado no J Med Chem (2015)

The mitochondrial proteins NLRX1 and TUFM form a complex that regulates type 1 interferon and autophagy

Por Lei, Yu, Wen, Haitao, Yu, Yanbao, Taxman, Debra J., Zhang, Lu, Widman, Douglas G., Swanson, Karen V., Wen, Kwun-Wah, Damania, Blossom, Moore, Chris B., Giguère, Patrick M., Siderovski, David P., Hiscott, John, Razani, Babak, Semenkovich, Clay F., Chen, Xian, Ting, Jenny P.-Y.
Publicado em 2012

Structure–based discovery of opioid analgesics with reduced side effects

Por Manglik, Aashish, Lin, Henry, Aryal, Dipendra K., McCorvy, John D., Dengler, Daniela, Corder, Gregory, Levit, Anat, Kling, Ralf C., Bernat, Viachaslau, Hübner, Harald, Huang, Xi-Ping, Sassano, Maria F., Giguère, Patrick M., Löber, Stefan, Duan, Da, Scherrer, Grégory, Kobilka, Brian K., Gmeiner, Peter, Roth, Bryan L., Shoichet, Brian K.
Publicado no Nature (2016)

A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior

Por Vardy, Eyal, Robinson, J. Elliott, Li, Chia, Olsen, Reid H. J., DiBerto, Jeffrey F., Giguere, Patrick M., Sassano, Flori M., Huang, Xi-Ping, Zhu, Hu, Urban, Daniel J., White, Kate L., Rittiner, Joseph E., Crowley, Nicole A., Pleil, Kristen E., Mazzone, Christopher M., Mosier, Philip D., Song, Juan, Kash, Thomas L., Malanga, C. J., Krashes, Michael J., Roth, Bryan L.
Publicado no Neuron (2015)

In Vitro and In Vivo Characterization of the Alkaloid Nuciferine

Por Farrell, Martilias S., McCorvy, John D., Huang, Xi-Ping, Urban, Daniel J., White, Kate L., Giguere, Patrick M., Doak, Allison K., Bernstein, Alison I., Stout, Kristen A., Park, Su Mi, Rodriguiz, Ramona M., Gray, Bradley W., Hyatt, William S., Norwood, Andrew P., Webster, Kevin A., Gannon, Brenda M., Miller, Gary W., Porter, Joseph H., Shoichet, Brian K., Fantegrossi, William E., Wetsel, William C., Roth, Bryan L.
Publicado no PLoS One (2016)