Structure–based discovery of opioid analgesics with reduced side effects

Morphine is an alkaloid from the opium poppy used to treat pain. The potentially lethal side effects of morphine and related opioids—which include fatal respiratory depression—are thought to be mediated by μ-opioid-receptor (μOR) signalling through the β-arrestin pathway or by actions at other recep...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Manglik, Aashish, Lin, Henry, Aryal, Dipendra K., McCorvy, John D., Dengler, Daniela, Corder, Gregory, Levit, Anat, Kling, Ralf C., Bernat, Viachaslau, Hübner, Harald, Huang, Xi-Ping, Sassano, Maria F., Giguère, Patrick M., Löber, Stefan, Duan, Da, Scherrer, Grégory, Kobilka, Brian K., Gmeiner, Peter, Roth, Bryan L., Shoichet, Brian K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5161585/
https://ncbi.nlm.nih.gov/pubmed/27533032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature19112
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