The mitochondrial proteins NLRX1 and TUFM form a complex that regulates type 1 interferon and autophagy

The mitochondrial protein MAVS (also known as IPS-1, VISA, CARDIF) interacts with RLR (RIG-I-like receptors) to induce type 1 interferon (IFN-I) during viral infection. NLRX1 is a mitochondrial NLR (nucleotide-binding, leucine-rich repeats containing) protein that attenuates MAVS-RLR signaling. Usin...

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Detalhes bibliográficos
Main Authors: Lei, Yu, Wen, Haitao, Yu, Yanbao, Taxman, Debra J., Zhang, Lu, Widman, Douglas G., Swanson, Karen V., Wen, Kwun-Wah, Damania, Blossom, Moore, Chris B., Giguère, Patrick M., Siderovski, David P., Hiscott, John, Razani, Babak, Semenkovich, Clay F., Chen, Xian, Ting, Jenny P.-Y.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3397828/
https://ncbi.nlm.nih.gov/pubmed/22749352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2012.03.025
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