RNA interference screen for RGS protein specificity at muscarinic and protease-activated receptors reveals bidirectional modulation of signaling

Regulator of G protein signaling (RGS) proteins are considered key modulators of G protein-coupled receptor (GPCR)-mediated signal transduction. These proteins act directly on Gα subunits in vitro to increase their intrinsic rate of GTP hydrolysis; this activity is central to the prevailing view of...

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Detalhes bibliográficos
Main Authors: Laroche, Geneviève, Giguère, Patrick M., Roth, Bryan L., Trejo, JoAnn, Siderovski, David P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2010
Assuntos:
Receptors and Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2944319/
https://ncbi.nlm.nih.gov/pubmed/20573995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00441.2009
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