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Regulation of Protease-activated Receptor 1 Signaling by the Adaptor Protein Complex 2 and R4 Subfamily of Regulator of G Protein Signaling Proteins

The G protein-coupled protease-activated receptor 1 (PAR1) is irreversibly proteolytically activated by thrombin. Hence, the precise regulation of PAR1 signaling is important for proper cellular responses. In addition to desensitization, internalization and lysosomal sorting of activated PAR1 are cr...

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Detalhes bibliográficos
Main Authors: Chen, Buxin, Siderovski, David P., Neubig, Richard R., Lawson, Mark A., Trejo, JoAnn
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3894338/
https://ncbi.nlm.nih.gov/pubmed/24297163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.528273
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