The α-arrestin ARRDC3 suppresses breast carcinoma invasion by regulating G protein–coupled receptor lysosomal sorting and signaling

Aberrant G protein–coupled receptor (GPCR) expression and activation has been linked to tumor initiation, progression, invasion, and metastasis. However, compared with other cancer drivers, the exploitation of GPCRs as potential therapeutic targets has been largely ignored, despite the fact that GPC...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Arakaki, Aleena K. S., Pan, Wen-An, Lin, Huilan, Trejo, JoAnn
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2018
Schlagworte:
Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5836114/
https://ncbi.nlm.nih.gov/pubmed/29348172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001516
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