The α-arrestin ARRDC3 suppresses breast carcinoma invasion by regulating G protein–coupled receptor lysosomal sorting and signaling

Aberrant G protein–coupled receptor (GPCR) expression and activation has been linked to tumor initiation, progression, invasion, and metastasis. However, compared with other cancer drivers, the exploitation of GPCRs as potential therapeutic targets has been largely ignored, despite the fact that GPC...

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Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Arakaki, Aleena K. S., Pan, Wen-An, Lin, Huilan, Trejo, JoAnn
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2018
Ämnen:
Signal Transduction
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5836114/
https://ncbi.nlm.nih.gov/pubmed/29348172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001516
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