Protease-activated receptor-4 and purinergic receptor P2Y12 dimerize, co-internalize, and activate Akt signaling via endosomal recruitment of β-arrestin

Vascular inflammation and thrombosis require the concerted actions of several different agonists, many of which act on G protein-coupled receptors (GPCRs). GPCR dimerization is a well-established phenomenon that can alter protomer function. In platelets and other cell types, protease-activated recep...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Smith, Thomas H., Li, Julia G., Dores, Michael R., Trejo, JoAnn
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2017
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5566538/
https://ncbi.nlm.nih.gov/pubmed/28652403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.782359
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