G Protein Signaling Modulator-3 Inhibits the Inflammasome Activity of NLRP3

Inflammasomes are multi-protein complexes that regulate maturation of the interleukin 1β-related cytokines IL-1β and IL-18 through activation of the cysteine proteinase caspase-1. NOD-like receptor family, pyrin domain containing 3 (NLRP3) protein is a key component of inflammasomes that assemble in...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Giguère, Patrick M., Gall, Bryan J., Ezekwe, Ejiofor A. D., Laroche, Geneviève, Buckley, Brian K., Kebaier, Chahnaz, Wilson, Justin E., Ting, Jenny P., Siderovski, David P., Duncan, Joseph A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4246083/
https://ncbi.nlm.nih.gov/pubmed/25271165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.578393
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