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The NLRP3 inflammasome: molecular activation and regulation to therapeutics
NLRP3 (NACHT, LRR and PYD domains-containing protein 3) is an intracellular sensor that detects a broad range of microbial motifs, endogenous danger signals and environmental irritants, resulting in the formation and activation of the NLRP3 inflammasome. Assembly of the NLRP3 inflammasome leads to c...
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| 發表在: | Nat Rev Immunol |
|---|---|
| Main Authors: | , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2019
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7807242/ https://ncbi.nlm.nih.gov/pubmed/31036962 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41577-019-0165-0 |
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