Catching a DUB in the act: novel ubiquitin-based active site directed probes

по Ekkebus, Reggy, Flierman, Dennis, Geurink, Paul P, Ovaa, Huib
Опубликовано в: Curr Opin Chem Biol (2014)

A General Chemical Ligation Approach Towards Isopeptide-Linked Ubiquitin and Ubiquitin-Like Assay Reagents

по Geurink, Paul P, Oualid, El Farid, Jonker, Anika, Hameed, Dharjath S, Ovaa, Huib
Опубликовано 2012

The Molecular Basis for Ubiquitin and Ubiquitin-like Specificities in Bacterial Effector Proteases

по Pruneda, Jonathan N., Durkin, Charlotte H., Geurink, Paul P., Ovaa, Huib, Santhanam, Balaji, Holden, David W., Komander, David
Опубликовано в: Mol Cell (2016)

Inhibition of the deubiquitinase Usp14 diminishes direct MHC class I antigen presentation

по Palmer, Amy L., de Jong, Annemieke, Leestemaker, Yves, Geurink, Paul P., Wijdeven, Ruud H., Ovaa, Huib, Dolan, Brian P.
Опубликовано в: J Immunol (2017)

Profiling DUBs and Ubl-specific proteases with activity-based probes

по Geurink, Paul P., van der Heden van Noort, Gerbrand J., Mulder, Monique P.C., Knaap, Robert C.M., Kikkert, Marjolein, Ovaa, Huib
Опубликовано в: Methods Enzymol (2019)

The novel β2-selective proteasome inhibitor LU-102 decreases phosphorylation of I kappa B and induces highly synergistic cytotoxicity in combination with ibrutinib in multiple myel...

по Kraus, Johannes, Kraus, Marianne, Liu, Nora, Besse, Lenka, Bader, Jürgen, Geurink, Paul P., de Bruin, Gerjan, Kisselev, Alexei F., Overkleeft, Herman, Driessen, Christoph
Опубликовано в: Cancer Chemother Pharmacol (2015)

Quantifying Positional Isomers (QPI) by Top-Down Mass Spectrometry

по Brunner, Andrea M., Lössl, Philip, Geurink, Paul P., Ovaa, Huib, Albanese, P., Altelaar, A.F. Maarten, Heck, Albert J.R., Scheltema, Richard A.
Опубликовано в: Mol Cell Proteomics (2021)

Non-hydrolyzable Diubiquitin Probes Reveal Linkage-Specific Reactivity of Deubiquitylating Enzymes Mediated by S2 Pockets

по Flierman, Dennis, van der Heden van Noort, Gerbrand J., Ekkebus, Reggy, Geurink, Paul P., Mevissen, Tycho E.T., Hospenthal, Manuela K., Komander, David, Ovaa, Huib
Опубликовано в: Cell Chem Biol (2016)

Structural basis of the specificity of USP18 toward ISG15

по Basters, Anja, Geurink, Paul P, Röcker, Annika, Witting, Katharina F, Tadayon, Roya, Hess, Sandra, Semrau, Marta S, Storici, Paola, Ovaa, Huib, Knobeloch, Klaus-Peter, Fritz, Günter
Опубликовано в: Nat Struct Mol Biol (2017)

Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos

по Kooij, Raymond, Liu, Sijia, Sapmaz, Aysegul, Xin, Bo-Tao, Janssen, George M. C., van Veelen, Peter A., Ovaa, Huib, Dijke, Peter ten, Geurink, Paul P.
Опубликовано в: J Am Chem Soc (2020)

On Terminal Alkynes That Can React with Active-Site Cysteine Nucleophiles in Proteases

по Ekkebus, Reggy, van Kasteren, Sander I., Kulathu, Yogesh, Scholten, Arjen, Berlin, Ilana, Geurink, Paul P., de Jong, Annemieke, Goerdayal, Soenita, Neefjes, Jacques, Heck, Albert J. R., Komander, David, Ovaa, Huib
Опубликовано 2013

Identification and characterization of diverse OTU deubiquitinases in bacteria

по Schubert, Alexander F, Nguyen, Justine V, Franklin, Tyler G, Geurink, Paul P, Roberts, Cameron G, Sanderson, Daniel J, Miller, Lauren N, Ovaa, Huib, Hofmann, Kay, Pruneda, Jonathan N, Komander, David
Опубликовано в: EMBO J (2020)

Incorporation of Fluorinated Phenylalanine Generates Highly Specific Inhibitor of Proteasome’s Chymotrypsin-like Sites

по Geurink, Paul P., Liu, Nora, Spaans, Michiel P., Downey, Sondra L., van den Nieuwendijk, Adrianus M. C. H., van der Marel, Gijsbert A., Kisselev, Alexei F., Florea, Bogdan I., Overkleeft, Herman S.
Опубликовано 2010

Kinetic analysis of multistep USP7 mechanism shows critical role for target protein in activity

по Kim, Robbert Q., Geurink, Paul P., Mulder, Monique P. C., Fish, Alexander, Ekkebus, Reggy, El Oualid, Farid, van Dijk, Willem J., van Dalen, Duco, Ovaa, Huib, van Ingen, Hugo, Sixma, Titia K.
Опубликовано в: Nat Commun (2019)

OTU Deubiquitinases Reveal Mechanisms of Linkage Specificity and Enable Ubiquitin Chain Restriction Analysis

по Mevissen, Tycho E.T., Hospenthal, Manuela K., Geurink, Paul P., Elliott, Paul R., Akutsu, Masato, Arnaudo, Nadia, Ekkebus, Reggy, Kulathu, Yogesh, Wauer, Tobias, El Oualid, Farid, Freund, Stefan M.V., Ovaa, Huib, Komander, David
Опубликовано 2013

Development of Diubiquitin‐Based FRET Probes To Quantify Ubiquitin Linkage Specificity of Deubiquitinating Enzymes

по Geurink, Paul P., van Tol, Bianca D. M., van Dalen, Duco, Brundel, Paul J. G., Mevissen, Tycho E. T., Pruneda, Jonathan N., Elliott, Paul R., van Tilburg, Gabriëlle B. A., Komander, David, Ovaa, Huib
Опубликовано в: Chembiochem (2016)

Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies

по Swatek, Kirby N., Aumayr, Martina, Pruneda, Jonathan N., Visser, Linda J., Berryman, Stephen, Kueck, Anja F., Geurink, Paul P., Ovaa, Huib, van Kuppeveld, Frank J. M., Tuthill, Tobias J., Skern, Tim, Komander, David
Опубликовано в: Proc Natl Acad Sci U S A (2018)

Nature of Pharmacophore Influences Active Site Specificity of Proteasome Inhibitors

по Screen, Michael, Britton, Matthew, Downey, Sondra L., Verdoes, Martijn, Voges, Mathias J., Blom, Annet E. M., Geurink, Paul P., Risseeuw, Martijn D. P., Florea, Bogdan I., van der Linden, Wouter A., Pletnev, Alexandre A., Overkleeft, Herman S., Kisselev, Alexei F.
Опубликовано 2010

The novel β2-selective proteasome inhibitor LU-102 synergizes with bortezomib and carfilzomib to overcome proteasome inhibitor resistance of myeloma cells

по Kraus, Marianne, Bader, Juergen, Geurink, Paul P., Weyburne, Emily S., Mirabella, Anne C., Silzle, Tobias, Shabaneh, Tamer B., van der Linden, Wouter A., de Bruin, Gerjan, Haile, Sarah R., van Rooden, Eva, Appenzeller, Christina, Li, Nan, Kisselev, Alexei F., Overkleeft, Herman, Driessen, Christoph
Опубликовано в: Haematologica (2015)

Downregulation of 26S proteasome catalytic activity promotes epithelial-mesenchymal transition

по Banno, Asoka, Garcia, Daniel A., van Baarsel, Eric D., Metz, Patrick J., Fisch, Kathleen, Widjaja, Christella E., Kim, Stephanie H., Lopez, Justine, Chang, Aaron N., Geurink, Paul P., Florea, Bogdan I., Overkleeft, Hermen S., Ovaa, Huib, Bui, Jack D., Yang, Jing, Chang, John T.
Опубликовано в: Oncotarget (2016)