Catching a DUB in the act: novel ubiquitin-based active site directed probes

od Ekkebus, Reggy, Flierman, Dennis, Geurink, Paul P, Ovaa, Huib
Izdano u Curr Opin Chem Biol (2014)

A General Chemical Ligation Approach Towards Isopeptide-Linked Ubiquitin and Ubiquitin-Like Assay Reagents

od Geurink, Paul P, Oualid, El Farid, Jonker, Anika, Hameed, Dharjath S, Ovaa, Huib
Izdano 2012

The Molecular Basis for Ubiquitin and Ubiquitin-like Specificities in Bacterial Effector Proteases

od Pruneda, Jonathan N., Durkin, Charlotte H., Geurink, Paul P., Ovaa, Huib, Santhanam, Balaji, Holden, David W., Komander, David
Izdano u Mol Cell (2016)

Inhibition of the deubiquitinase Usp14 diminishes direct MHC class I antigen presentation

od Palmer, Amy L., de Jong, Annemieke, Leestemaker, Yves, Geurink, Paul P., Wijdeven, Ruud H., Ovaa, Huib, Dolan, Brian P.
Izdano u J Immunol (2017)

Profiling DUBs and Ubl-specific proteases with activity-based probes

od Geurink, Paul P., van der Heden van Noort, Gerbrand J., Mulder, Monique P.C., Knaap, Robert C.M., Kikkert, Marjolein, Ovaa, Huib
Izdano u Methods Enzymol (2019)

The novel β2-selective proteasome inhibitor LU-102 decreases phosphorylation of I kappa B and induces highly synergistic cytotoxicity in combination with ibrutinib in multiple myel...

od Kraus, Johannes, Kraus, Marianne, Liu, Nora, Besse, Lenka, Bader, Jürgen, Geurink, Paul P., de Bruin, Gerjan, Kisselev, Alexei F., Overkleeft, Herman, Driessen, Christoph
Izdano u Cancer Chemother Pharmacol (2015)

Quantifying Positional Isomers (QPI) by Top-Down Mass Spectrometry

od Brunner, Andrea M., Lössl, Philip, Geurink, Paul P., Ovaa, Huib, Albanese, P., Altelaar, A.F. Maarten, Heck, Albert J.R., Scheltema, Richard A.
Izdano u Mol Cell Proteomics (2021)

Non-hydrolyzable Diubiquitin Probes Reveal Linkage-Specific Reactivity of Deubiquitylating Enzymes Mediated by S2 Pockets

od Flierman, Dennis, van der Heden van Noort, Gerbrand J., Ekkebus, Reggy, Geurink, Paul P., Mevissen, Tycho E.T., Hospenthal, Manuela K., Komander, David, Ovaa, Huib
Izdano u Cell Chem Biol (2016)

Structural basis of the specificity of USP18 toward ISG15

od Basters, Anja, Geurink, Paul P, Röcker, Annika, Witting, Katharina F, Tadayon, Roya, Hess, Sandra, Semrau, Marta S, Storici, Paola, Ovaa, Huib, Knobeloch, Klaus-Peter, Fritz, Günter
Izdano u Nat Struct Mol Biol (2017)

Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos

od Kooij, Raymond, Liu, Sijia, Sapmaz, Aysegul, Xin, Bo-Tao, Janssen, George M. C., van Veelen, Peter A., Ovaa, Huib, Dijke, Peter ten, Geurink, Paul P.
Izdano u J Am Chem Soc (2020)

On Terminal Alkynes That Can React with Active-Site Cysteine Nucleophiles in Proteases

od Ekkebus, Reggy, van Kasteren, Sander I., Kulathu, Yogesh, Scholten, Arjen, Berlin, Ilana, Geurink, Paul P., de Jong, Annemieke, Goerdayal, Soenita, Neefjes, Jacques, Heck, Albert J. R., Komander, David, Ovaa, Huib
Izdano 2013

Identification and characterization of diverse OTU deubiquitinases in bacteria

od Schubert, Alexander F, Nguyen, Justine V, Franklin, Tyler G, Geurink, Paul P, Roberts, Cameron G, Sanderson, Daniel J, Miller, Lauren N, Ovaa, Huib, Hofmann, Kay, Pruneda, Jonathan N, Komander, David
Izdano u EMBO J (2020)

Incorporation of Fluorinated Phenylalanine Generates Highly Specific Inhibitor of Proteasome’s Chymotrypsin-like Sites

od Geurink, Paul P., Liu, Nora, Spaans, Michiel P., Downey, Sondra L., van den Nieuwendijk, Adrianus M. C. H., van der Marel, Gijsbert A., Kisselev, Alexei F., Florea, Bogdan I., Overkleeft, Herman S.
Izdano 2010

Kinetic analysis of multistep USP7 mechanism shows critical role for target protein in activity

od Kim, Robbert Q., Geurink, Paul P., Mulder, Monique P. C., Fish, Alexander, Ekkebus, Reggy, El Oualid, Farid, van Dijk, Willem J., van Dalen, Duco, Ovaa, Huib, van Ingen, Hugo, Sixma, Titia K.
Izdano u Nat Commun (2019)

OTU Deubiquitinases Reveal Mechanisms of Linkage Specificity and Enable Ubiquitin Chain Restriction Analysis

od Mevissen, Tycho E.T., Hospenthal, Manuela K., Geurink, Paul P., Elliott, Paul R., Akutsu, Masato, Arnaudo, Nadia, Ekkebus, Reggy, Kulathu, Yogesh, Wauer, Tobias, El Oualid, Farid, Freund, Stefan M.V., Ovaa, Huib, Komander, David
Izdano 2013

Development of Diubiquitin‐Based FRET Probes To Quantify Ubiquitin Linkage Specificity of Deubiquitinating Enzymes

od Geurink, Paul P., van Tol, Bianca D. M., van Dalen, Duco, Brundel, Paul J. G., Mevissen, Tycho E. T., Pruneda, Jonathan N., Elliott, Paul R., van Tilburg, Gabriëlle B. A., Komander, David, Ovaa, Huib
Izdano u Chembiochem (2016)

Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies

od Swatek, Kirby N., Aumayr, Martina, Pruneda, Jonathan N., Visser, Linda J., Berryman, Stephen, Kueck, Anja F., Geurink, Paul P., Ovaa, Huib, van Kuppeveld, Frank J. M., Tuthill, Tobias J., Skern, Tim, Komander, David
Izdano u Proc Natl Acad Sci U S A (2018)

Nature of Pharmacophore Influences Active Site Specificity of Proteasome Inhibitors

od Screen, Michael, Britton, Matthew, Downey, Sondra L., Verdoes, Martijn, Voges, Mathias J., Blom, Annet E. M., Geurink, Paul P., Risseeuw, Martijn D. P., Florea, Bogdan I., van der Linden, Wouter A., Pletnev, Alexandre A., Overkleeft, Herman S., Kisselev, Alexei F.
Izdano 2010

The novel β2-selective proteasome inhibitor LU-102 synergizes with bortezomib and carfilzomib to overcome proteasome inhibitor resistance of myeloma cells

od Kraus, Marianne, Bader, Juergen, Geurink, Paul P., Weyburne, Emily S., Mirabella, Anne C., Silzle, Tobias, Shabaneh, Tamer B., van der Linden, Wouter A., de Bruin, Gerjan, Haile, Sarah R., van Rooden, Eva, Appenzeller, Christina, Li, Nan, Kisselev, Alexei F., Overkleeft, Herman, Driessen, Christoph
Izdano u Haematologica (2015)

Downregulation of 26S proteasome catalytic activity promotes epithelial-mesenchymal transition

od Banno, Asoka, Garcia, Daniel A., van Baarsel, Eric D., Metz, Patrick J., Fisch, Kathleen, Widjaja, Christella E., Kim, Stephanie H., Lopez, Justine, Chang, Aaron N., Geurink, Paul P., Florea, Bogdan I., Overkleeft, Hermen S., Ovaa, Huib, Bui, Jack D., Yang, Jing, Chang, John T.
Izdano u Oncotarget (2016)