Effects of oncogenic mutations on the conformational free-energy landscape of EGFR kinase

di Sutto, Ludovico, Gervasio, Francesco Luigi
Pubblicazione 2013

Editorial: Machine Learning in Biomolecular Simulations

di Verkhivker, Gennady, Spiwok, Vojtech, Gervasio, Francesco Luigi
Pubblicato in Front Mol Biosci (2019)

From residue coevolution to protein conformational ensembles and functional dynamics

di Sutto, Ludovico, Marsili, Simone, Valencia, Alfonso, Gervasio, Francesco Luigi
Pubblicato in Proc Natl Acad Sci U S A (2015)

A combined activation mechanism for the glucagon receptor

di Mattedi, Giulio, Acosta-Gutiérrez, Silvia, Clark, Timothy, Gervasio, Francesco Luigi
Pubblicato in Proc Natl Acad Sci U S A (2020)

Molecular basis of cyclooxygenase enzymes (COXs) selective inhibition

di Limongelli, Vittorio, Bonomi, Massimiliano, Marinelli, Luciana, Gervasio, Francesco Luigi, Cavalli, Andrea, Novellino, Ettore, Parrinello, Michele
Pubblicazione 2010

Structural basis of the effect of activating mutations on the EGF receptor

di Galdadas, Ioannis, Carlino, Luca, Ward, Richard A, Hughes, Samantha J, Haider, Shozeb, Gervasio, Francesco Luigi
Pubblicato in eLife (2021)

Molecular engineering of polymersome surface topology

di Ruiz-Pérez, Lorena, Messager, Lea, Gaitzsch, Jens, Joseph, Adrian, Sutto, Ludovico, Gervasio, Francesco Luigi, Battaglia, Giuseppe
Pubblicato in Sci Adv (2016)

The Role of Post-translational Modifications on the Energy Landscape of Huntingtin N-Terminus

di Yalinca, Havva, Gehin, Charlotte Julie Caroline, Oleinikovas, Vladimiras, Lashuel, Hilal A., Gervasio, Francesco Luigi, Pastore, Annalisa
Pubblicato in Front Mol Biosci (2019)

Changes in the folding landscape of the WW domain provide a molecular mechanism for an inherited genetic syndrome

di Pucheta-Martinez, Encarna, D’Amelio, Nicola, Lelli, Moreno, Martinez-Torrecuadrada, Jorge L., Sudol, Marius, Saladino, Giorgio, Gervasio, Francesco Luigi
Pubblicato in Sci Rep (2016)

DNA-binding protects p53 from interactions with cofactors involved in transcription-independent functions

di Lambrughi, Matteo, De Gioia, Luca, Gervasio, Francesco Luigi, Lindorff-Larsen, Kresten, Nussinov, Ruth, Urani, Chiara, Bruschi, Maurizio, Papaleo, Elena
Pubblicato in Nucleic Acids Res (2016)

Intrinsically active MEK variants are differentially regulated by proteinases and phosphatases

di Ordan, Merav, Pallara, Chiara, Maik-Rachline, Galia, Hanoch, Tamar, Gervasio, Francesco Luigi, Glaser, Fabian, Fernandez-Recio, Juan, Seger, Rony
Pubblicato in Sci Rep (2018)

An Allosteric Cross-Talk Between the Activation Loop and the ATP Binding Site Regulates the Activation of Src Kinase

di Pucheta-Martínez, Encarna, Saladino, Giorgio, Morando, Maria Agnese, Martinez-Torrecuadrada, Jorge, Lelli, Moreno, Sutto, Ludovico, D’Amelio, Nicola, Gervasio, Francesco Luigi
Pubblicato in Sci Rep (2016)

Concurrent mutations in RNA-dependent RNA polymerase and spike protein emerged as the epidemiologically most successful SARS-CoV-2 variant

di Ilmjärv, Sten, Abdul, Fabien, Acosta-Gutiérrez, Silvia, Estarellas, Carolina, Galdadas, Ioannis, Casimir, Marina, Alessandrini, Marco, Gervasio, Francesco Luigi, Krause, Karl-Heinz
Pubblicato in Sci Rep (2021)

Architecture of the MKK6-p38α complex defines the basis of MAPK specificity and activation

di Juyoux, Pauline, Galdadas, Ioannis, Gobbo, Dorothea, von Velsen, Jill, Pelosse, Martin, Tully, Mark, Vadas, Oscar, Gervasio, Francesco Luigi, Pellegrini, Erika, Bowler, Matthew W.
Pubblicato in Science (2023)

Conformational Selection and Induced Fit Mechanisms in the Binding of an Anticancer Drug to the c-Src Kinase

di Morando, Maria Agnese, Saladino, Giorgio, D’Amelio, Nicola, Pucheta-Martinez, Encarna, Lovera, Silvia, Lelli, Moreno, López-Méndez, Blanca, Marenchino, Marco, Campos-Olivas, Ramón, Gervasio, Francesco Luigi
Pubblicato in Sci Rep (2016)

Non-specific protein–DNA interactions control I-CreI target binding and cleavage

di Molina, Rafael, Redondo, Pilar, Stella, Stefano, Marenchino, Marco, D’Abramo, Marco, Gervasio, Francesco Luigi, Charles Epinat, Jean, Valton, Julien, Grizot, Silvestre, Duchateau, Phillipe, Prieto, Jesús, Montoya, Guillermo
Pubblicazione 2012

Conformational transition of FGFR kinase activation revealed by site-specific unnatural amino acid reporter and single molecule FRET

di Perdios, Louis, Lowe, Alan R., Saladino, Giorgio, Bunney, Tom D., Thiyagarajan, Nethaji, Alexandrov, Yuriy, Dunsby, Christopher, French, Paul M. W., Chin, Jason W., Gervasio, Francesco Luigi, Tate, Edward W., Katan, Matilda
Pubblicato in Sci Rep (2017)

Phosphatidylinositol 4,5-bisphosphate triggers activation of focal adhesion kinase by inducing clustering and conformational changes

di Goñi, Guillermina M., Epifano, Carolina, Boskovic, Jasminka, Camacho-Artacho, Marta, Zhou, Jing, Bronowska, Agnieszka, Martín, M. Teresa, Eck, Michael J., Kremer, Leonor, Gräter, Frauke, Gervasio, Francesco Luigi, Perez-Moreno, Mirna, Lietha, Daniel
Pubblicazione 2014

Allosteric communication in class A β-lactamases occurs via cooperative coupling of loop dynamics

di Galdadas, Ioannis, Qu, Shen, Oliveira, Ana Sofia F, Olehnovics, Edgar, Mack, Andrew R, Mojica, Maria F, Agarwal, Pratul K, Tooke, Catherine L, Gervasio, Francesco Luigi, Spencer, James, Bonomo, Robert A, Mulholland, Adrian J, Haider, Shozeb
Pubblicato in eLife (2021)