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The Role of Post-translational Modifications on the Energy Landscape of Huntingtin N-Terminus
Huntington disease is a neurodegenerative disease characterized by a polymorphic tract of polyglutamine repeats in exon 1 of the huntingtin protein, which is thought to be responsible for protein aggregation and neuronal death. The polyglutamine tract is preceded by a 17-residue sequence that is int...
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| Publicado no: | Front Mol Biosci |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6779701/ https://ncbi.nlm.nih.gov/pubmed/31632982 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2019.00095 |
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