The Role of Post-translational Modifications on the Energy Landscape of Huntingtin N-Terminus

Huntington disease is a neurodegenerative disease characterized by a polymorphic tract of polyglutamine repeats in exon 1 of the huntingtin protein, which is thought to be responsible for protein aggregation and neuronal death. The polyglutamine tract is preceded by a 17-residue sequence that is int...

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Veröffentlicht in:Front Mol Biosci
Hauptverfasser: Yalinca, Havva, Gehin, Charlotte Julie Caroline, Oleinikovas, Vladimiras, Lashuel, Hilal A., Gervasio, Francesco Luigi, Pastore, Annalisa
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019
Schlagworte:
Molecular Biosciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6779701/
https://ncbi.nlm.nih.gov/pubmed/31632982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2019.00095
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