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Post-translational modifications clustering within proteolytic domains decrease mutant huntingtin toxicity

Huntington's disease (HD) is caused in large part by a polyglutamine expansion within the huntingtin (Htt) protein. Post-translational modifications (PTMs) control and regulate many protein functions and cellular pathways, and PTMs of mutant Htt are likely important modulators of HD pathogenesi...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:J Biol Chem
मुख्य लेखकों: Arbez, Nicolas, Ratovitski, Tamara, Roby, Elaine, Chighladze, Ekaterine, Stewart, Jacqueline C., Ren, Mark, Wang, Xiaofang, Lavery, Daniel J., Ross, Christopher A.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society for Biochemistry and Molecular Biology 2017
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5702665/
https://ncbi.nlm.nih.gov/pubmed/28972180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.782300
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