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Post-translational modifications clustering within proteolytic domains decrease mutant huntingtin toxicity
Huntington's disease (HD) is caused in large part by a polyglutamine expansion within the huntingtin (Htt) protein. Post-translational modifications (PTMs) control and regulate many protein functions and cellular pathways, and PTMs of mutant Htt are likely important modulators of HD pathogenesi...
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| Publicado no: | J Biol Chem |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5702665/ https://ncbi.nlm.nih.gov/pubmed/28972180 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.782300 |
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