A carregar...

Post-translational modifications clustering within proteolytic domains decrease mutant huntingtin toxicity

Huntington's disease (HD) is caused in large part by a polyglutamine expansion within the huntingtin (Htt) protein. Post-translational modifications (PTMs) control and regulate many protein functions and cellular pathways, and PTMs of mutant Htt are likely important modulators of HD pathogenesi...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Arbez, Nicolas, Ratovitski, Tamara, Roby, Elaine, Chighladze, Ekaterine, Stewart, Jacqueline C., Ren, Mark, Wang, Xiaofang, Lavery, Daniel J., Ross, Christopher A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5702665/
https://ncbi.nlm.nih.gov/pubmed/28972180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.782300
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!