Phosphorylation of Mutant Huntingtin at Serine 116 Modulates Neuronal Toxicity

Phosphorylation has been shown to have a significant impact on expanded huntingtin-mediated cellular toxicity. Several phosphorylation sites have been identified on the huntingtin (Htt) protein. To find new potential therapeutic targets for Huntington's Disease (HD), we used mass spectrometry t...

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Bibliographische Detailangaben
Hauptverfasser: Watkin, Erin E., Arbez, Nicolas, Waldron-Roby, Elaine, O'Meally, Robert, Ratovitski, Tamara, Cole, Robert N., Ross, Christopher A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3914950/
https://ncbi.nlm.nih.gov/pubmed/24505464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0088284
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