Transgenic Mouse Model Expressing the Caspase 6 Fragment of Mutant Huntingtin

Huntington's disease (HD) is caused by a polyglutamine expansion in the Huntingtin (Htt) protein. Proteolytic cleavage of Htt into toxic N-terminal fragments is believed to be a key aspect of pathogenesis. The best characterized putative cleavage event is at amino acid 586, hypothesized to be m...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Waldron-Roby, Elaine, Ratovitski, Tamara, Wang, XiaoFang, Jiang, Mali, Watkin, Erin, Arbez, Nikolas, Graham, Rona K., Hayden, Michael R., Hou, Zhipeng, Mori, Susumu, Swing, Deborah, Pletnikov, Mikhail, Duan, Wenzhen, Tessarollo, Lino, Ross, Christopher A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Society for Neuroscience 2012
Aiheet:
Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3306223/
https://ncbi.nlm.nih.gov/pubmed/22219281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1305-11.2012
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia