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Premature death and neurologic abnormalities in transgenic mice expressing a mutant huntingtin exon-2 fragment
Huntington's disease (HD) is a fatal neurodegenerative disease characterized pathologically by aggregates composed of N-terminal fragments of the mutant form of the protein huntingtin (htt). The role of these N-terminal fragments in disease pathogenesis has been questioned based in part on stud...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Oxford University Press
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3063989/ https://ncbi.nlm.nih.gov/pubmed/21307087 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddr040 |
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