Mutant Huntingtin N-terminal Fragments of Specific Size Mediate Aggregation and Toxicity in Neuronal Cells

Huntingtin proteolysis is implicated in Huntington disease pathogenesis, yet, the nature of huntingtin toxic fragments remains unclear. Huntingtin undergoes proteolysis by calpains and caspases within an N-terminal region between amino acids 460 and 600. We have focused on proteolytic steps producin...

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Detalhes bibliográficos
Main Authors: Ratovitski, Tamara, Gucek, Marjan, Jiang, Haibing, Chighladze, Ekaterine, Waldron, Elaine, D'Ambola, James, Hou, Zhipeng, Liang, Yideng, Poirier, Michelle A., Hirschhorn, Ricky R., Graham, Rona, Hayden, Michael R., Cole, Robert N., Ross, Christopher A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Protein Synthesis, Post-Translational Modification, and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2667772/
https://ncbi.nlm.nih.gov/pubmed/19204007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804813200
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