Mutant Huntingtin N-terminal Fragments of Specific Size Mediate Aggregation and Toxicity in Neuronal Cells

Huntingtin proteolysis is implicated in Huntington disease pathogenesis, yet, the nature of huntingtin toxic fragments remains unclear. Huntingtin undergoes proteolysis by calpains and caspases within an N-terminal region between amino acids 460 and 600. We have focused on proteolytic steps producin...

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Dades bibliogràfiques
Autors principals: Ratovitski, Tamara, Gucek, Marjan, Jiang, Haibing, Chighladze, Ekaterine, Waldron, Elaine, D'Ambola, James, Hou, Zhipeng, Liang, Yideng, Poirier, Michelle A., Hirschhorn, Ricky R., Graham, Rona, Hayden, Michael R., Cole, Robert N., Ross, Christopher A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2009
Matèries:
Protein Synthesis, Post-Translational Modification, and Degradation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2667772/
https://ncbi.nlm.nih.gov/pubmed/19204007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804813200
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