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Huntingtin protein interactions altered by polyglutamine expansion as determined by quantitative proteomic analysis
Huntington disease (HD) is a neurodegenerative disorder caused by an expansion of a polyglutamine repeat within the HD gene product, huntingtin. Huntingtin, a large (347 kDa) protein containing multiple HEAT repeats, acts as a scaffold for protein-protein interactions. Huntingtin-induced toxicity is...
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| Main Authors: | , , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Landes Bioscience
2012
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3359124/ https://ncbi.nlm.nih.gov/pubmed/22580459 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.20423 |
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