Expansion of polyglutamine repeat in huntingtin leads to abnormal protein interactions involving calmodulin.

Huntington's disease (HD) is an inherited neurodegenerative disorder associated with expansion of a CAG repeat in the IT15 gene. The IT15 gene is translated to a protein product termed huntingtin that contains a polyglutamine (polyGln) tract. Recent investigations indicate that the cause of HD...

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Detalhes bibliográficos
Main Authors: Bao, J, Sharp, A H, Wagster, M V, Becher, M, Schilling, G, Ross, C A, Dawson, V L, Dawson, T M
Formato: Artigo
Idioma:Inglês
Publicado em: 1996
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC39402/
https://ncbi.nlm.nih.gov/pubmed/8643525
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