Polyglutamine expansion affects huntingtin conformation in multiple Huntington’s disease models

Conformational changes in disease-associated or mutant proteins represent a key pathological aspect of Huntington’s disease (HD) and other protein misfolding diseases. Using immunoassays and biophysical approaches, we and others have recently reported that polyglutamine expansion in purified or reco...

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Publicat a:Sci Rep
Autors principals: Daldin, Manuel, Fodale, Valentina, Cariulo, Cristina, Azzollini, Lucia, Verani, Margherita, Martufi, Paola, Spiezia, Maria Carolina, Deguire, Sean M., Cherubini, Marta, Macdonald, Douglas, Weiss, Andreas, Bresciani, Alberto, Vonsattel, Jean-Paul Gerard, Petricca, Lara, Marsh, J. Lawrence, Gines, Silvia, Santimone, Iolanda, Marano, Massimo, Lashuel, Hilal A., Squitieri, Ferdinando, Caricasole, Andrea
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5505970/
https://ncbi.nlm.nih.gov/pubmed/28698602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-05336-7
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