Polyglutamine expansion affects huntingtin conformation in multiple Huntington’s disease models

Conformational changes in disease-associated or mutant proteins represent a key pathological aspect of Huntington’s disease (HD) and other protein misfolding diseases. Using immunoassays and biophysical approaches, we and others have recently reported that polyglutamine expansion in purified or reco...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Sci Rep
Päätekijät: Daldin, Manuel, Fodale, Valentina, Cariulo, Cristina, Azzollini, Lucia, Verani, Margherita, Martufi, Paola, Spiezia, Maria Carolina, Deguire, Sean M., Cherubini, Marta, Macdonald, Douglas, Weiss, Andreas, Bresciani, Alberto, Vonsattel, Jean-Paul Gerard, Petricca, Lara, Marsh, J. Lawrence, Gines, Silvia, Santimone, Iolanda, Marano, Massimo, Lashuel, Hilal A., Squitieri, Ferdinando, Caricasole, Andrea
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2017
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5505970/
https://ncbi.nlm.nih.gov/pubmed/28698602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-05336-7
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