Phosphorylation of huntingtin at residue T3 is decreased in Huntington’s disease and modulates mutant huntingtin protein conformation

Posttranslational modifications can have profound effects on the biological and biophysical properties of proteins associated with misfolding and aggregation. However, their detection and quantification in clinical samples and an understanding of the mechanisms underlying the pathological properties...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Cariulo, Cristina, Azzollini, Lucia, Verani, Margherita, Martufi, Paola, Boggio, Roberto, Chiki, Anass, Deguire, Sean M., Cherubini, Marta, Gines, Silvia, Marsh, J. Lawrence, Conforti, Paola, Cattaneo, Elena, Santimone, Iolanda, Squitieri, Ferdinando, Lashuel, Hilal A., Petricca, Lara, Caricasole, Andrea
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5740681/
https://ncbi.nlm.nih.gov/pubmed/29162692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1705372114
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