N-terminal Huntingtin (Htt) phosphorylation is a molecular switch regulating Htt aggregation, helical conformation, internalization, and nuclear targeting

Huntington's disease is a fatal neurodegenerative disorder resulting from a CAG repeat expansion in the first exon of the gene encoding the Huntingtin protein (Htt). Phosphorylation of this protein region (Httex1) has been shown to play important roles in regulating the structure, toxicity, and...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: DeGuire, Sean M., Ruggeri, Francesco S., Fares, Mohamed-Bilal, Chiki, Anass, Cendrowska, Urszula, Dietler, Giovanni, Lashuel, Hilal A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6290154/
https://ncbi.nlm.nih.gov/pubmed/30185623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004621
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