Nucleation inhibition of Huntingtin protein (htt) by polyproline PPII helices: a potential interaction with the N-terminal α-helical region of htt

Huntington’s disease (HD) is a genetic neurodegenerative disorder characterized by the formation of amyloid fibrils of the huntingtin protein (htt). The seventeen-residue N-terminal region of htt (Nt(17)) has been implicated in formation of early-phase oligomeric species, which may be neurotoxic. Be...

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Vydáno v:Biochemistry
Hlavní autoři: Arndt, James R, Chaibva, Maxmore, Beasley, Maryssa, Karanji, Ahmad Kiani, Kondalaji, Samaneh Ghassabi, Khakinejad, Mahdiar, Sarver, Olivia, Legleiter, Justin, Valentine, Stephen J
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7344267/
https://ncbi.nlm.nih.gov/pubmed/31814404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b00689
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