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The emerging role of the first 17 amino acids of huntingtin in Huntington’s disease
Huntington’s disease (HD) is caused by a polyglutamine (polyQ) domain that is expanded beyond a critical threshold near the N-terminus of the huningtin (htt) protein, directly leading to htt aggregation. While full-length htt is a large (on the order of ~350 kDa) protein, it is proteolyzed into a va...
Shranjeno v:
| izdano v: | Biomol Concepts |
|---|---|
| Main Authors: | , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2015
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4590289/ https://ncbi.nlm.nih.gov/pubmed/25741791 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1515/bmc-2015-0001 |
| Oznake: |
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