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Cholesterol Modifies Huntingtin Binding to, Disruption of, and Aggregation on Lipid Membranes
Huntington’s disease (HD) is an inherited neurodegenerative disease caused by abnormally long CAG-repeats in the huntingtin gene that encode an expanded polyglutamine (polyQ) domain near the N-terminus of the huntingtin (htt) protein. Expanded polyQ domains are directly correlated to disease-related...
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| Publicado en: | Biochemistry |
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| Autores principales: | , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4956082/ https://ncbi.nlm.nih.gov/pubmed/26652744 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00900 |
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