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Cholesterol Modifies Huntingtin Binding to, Disruption of, and Aggregation on Lipid Membranes

Huntington’s disease (HD) is an inherited neurodegenerative disease caused by abnormally long CAG-repeats in the huntingtin gene that encode an expanded polyglutamine (polyQ) domain near the N-terminus of the huntingtin (htt) protein. Expanded polyQ domains are directly correlated to disease-related...

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Bibliografische gegevens
Gepubliceerd in:Biochemistry
Hoofdauteurs: Gao, Xiang, Campbell, Warren A., Chaibva, Maxmore, Jain, Pranav, Leslie, Ashley E., Frey, Shelli L., Legleiter, Justin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4956082/
https://ncbi.nlm.nih.gov/pubmed/26652744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00900
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