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Nucleation inhibition of Huntingtin protein (htt) by polyproline PPII helices: a potential interaction with the N-terminal α-helical region of htt
Huntington’s disease (HD) is a genetic neurodegenerative disorder characterized by the formation of amyloid fibrils of the huntingtin protein (htt). The seventeen-residue N-terminal region of htt (Nt(17)) has been implicated in formation of early-phase oligomeric species, which may be neurotoxic. Be...
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| Publicado no: | Biochemistry |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7344267/ https://ncbi.nlm.nih.gov/pubmed/31814404 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b00689 |
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