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Conformational switch of polyglutamine-expanded huntingtin into benign aggregates leads to neuroprotective effect
The abundant accumulation of inclusion bodies containing polyglutamine-expanded mutant huntingtin (mHTT) aggregates is considered as the key pathological event in Huntington’s disease (HD). Here, we demonstrate that FKBP12, an isomerase that exhibits reduced expression in HD, decreases the amyloidog...
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| Yayımlandı: | Sci Rep |
|---|---|
| Asıl Yazarlar: | , , , , , , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Nature Publishing Group
2015
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4598856/ https://ncbi.nlm.nih.gov/pubmed/26450664 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep14992 |
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