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Conformational switch of polyglutamine-expanded huntingtin into benign aggregates leads to neuroprotective effect

The abundant accumulation of inclusion bodies containing polyglutamine-expanded mutant huntingtin (mHTT) aggregates is considered as the key pathological event in Huntington’s disease (HD). Here, we demonstrate that FKBP12, an isomerase that exhibits reduced expression in HD, decreases the amyloidog...

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Detaylı Bibliyografya
Yayımlandı:Sci Rep
Asıl Yazarlar: Sun, Chia-Sui, Lee, Chi-Chang, Li, Yi-Ni, Yao-Chen Yang, Sunny, Lin, Chih-Hsiang, Chang, Yi-Che, Liu, Po-Fan, He, Ruei-Yu, Wang, Chih-Hsien, Chen, Wenlung, Chern, Yijuang, Jen-Tse Huang, Joseph
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2015
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4598856/
https://ncbi.nlm.nih.gov/pubmed/26450664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep14992
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