The Influence of Pathological Mutations and Proline Substitutions in TDP-43 Glycine-Rich Peptides on Its Amyloid Properties and Cellular Toxicity

TAR DNA-binding protein (TDP-43) was identified as the major ubiquitinated component deposited in the inclusion bodies in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U) in 2006. Later on, numerous ALS-related mutations were found...

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Main Authors: Sun, Chia-Sui, Wang, Cindy Yu-Hsiang, Chen, Bryan Po-Wen, He, Ruei-Yu, Liu, Gerard Chun-Hao, Wang, Chih-Hsien, Chen, Wenlung, Chern, Yijuang, Huang, Joseph Jen-Tse
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4121164/
https://ncbi.nlm.nih.gov/pubmed/25090004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0103644
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