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Quantification Assays for Total and Polyglutamine-Expanded Huntingtin Proteins
The expansion of a CAG trinucleotide repeat in the huntingtin gene, which produces huntingtin protein with an expanded polyglutamine tract, is the cause of Huntington's disease (HD). Recent studies have reported that RNAi suppression of polyglutamine-expanded huntingtin (mutant HTT) in HD anima...
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| Hauptverfasser: | , , , , , , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4016121/ https://ncbi.nlm.nih.gov/pubmed/24816435 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0096854 |
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