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Impaired Heat Shock Response in Cells Expressing Full-Length Polyglutamine-Expanded Huntingtin
The molecular mechanisms by which polyglutamine (polyQ)-expanded huntingtin (Htt) causes neurodegeneration in Huntington's disease (HD) remain unclear. The malfunction of cellular proteostasis has been suggested as central in HD pathogenesis and also as a target of therapeutic interventions for...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3359295/ https://ncbi.nlm.nih.gov/pubmed/22649566 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0037929 |
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