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Reversal of a full-length mutant huntingtin neuronal cell phenotype by chemical inhibitors of polyglutamine-mediated aggregation
BACKGROUND: Huntington's disease (HD) is an inherited neurodegenerative disorder triggered by an expanded polyglutamine tract in huntingtin that is thought to confer a new conformational property on this large protein. The propensity of small amino-terminal fragments with mutant, but not wild-t...
Uloženo v:
| Vydáno v: | BMC Neurosci |
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| Hlavní autoři: | , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
BMC
2005
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC548150/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15649316/ https://ncbi.nlm.nih.govhttps://doi.org/10.1186/1471-2202-6-1 |
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