Striatal neurons expressing full-length mutant huntingtin exhibit decreased N-cadherin and altered neuritogenesis

The expanded CAG repeat that causes striatal cell vulnerability in Huntington's disease (HD) encodes a polyglutamine tract in full-length huntingtin that is correlated with cellular [ATP] and [ATP/ADP]. Since striatal neurons are vulnerable to energy deficit, we have investigated, in Hdh CAG kn...

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Hauptverfasser: Reis, Surya A., Thompson, Morgan N., Lee, Jong-Min, Fossale, Elisa, Kim, Hyung-Hwan, Liao, James K., Moskowitz, Michael A., Shaw, Stanley Y., Dong, Linda, Haggarty, Stephen J., MacDonald, Marcy E., Seong, Ihn Sik
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2011
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3098733/
https://ncbi.nlm.nih.gov/pubmed/21447599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddr127
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