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Full sequence of mutant huntingtin 3’-untranslated region and modulation of its gene regulatory activity by endogenous microRNA
Huntington’s disease (HD) is caused by an expanded CAG trinucleotide repeat in the first exon of the huntingtin gene (HTT). Since the entire course of the disease starts from this dominant gain-of-function mutation, lowering total or mutant huntingtin mRNA/protein has emerged as an appealing therape...
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| Publicado en: | J Hum Genet |
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| Autores principales: | , , , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7324902/ https://ncbi.nlm.nih.gov/pubmed/31296921 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s10038-019-0639-8 |
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