Full sequence of mutant huntingtin 3’-untranslated region and modulation of its gene regulatory activity by endogenous microRNA

Huntington’s disease (HD) is caused by an expanded CAG trinucleotide repeat in the first exon of the huntingtin gene (HTT). Since the entire course of the disease starts from this dominant gain-of-function mutation, lowering total or mutant huntingtin mRNA/protein has emerged as an appealing therape...

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Bibliografiske detaljer
Udgivet i:J Hum Genet
Main Authors: Kim, Kyung-Hee, Elneel, Kawther Abu, Shin, Jun Wan, Keum, Jae Whan, Seong, David, Kwak, Seung, Lee, Ramee, Gusella, James F., MacDonald, Marcy E., Seong, Ihn Sik, Lee, Jong-Min
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7324902/
https://ncbi.nlm.nih.gov/pubmed/31296921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s10038-019-0639-8
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